SELECTBIO Conferences Flow Chemistry Asia 2022

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同時開催される会議のアジェンダ

Flow Chemistry Asia 2022  |  3D-Bioprinting, Biofabrication, Organoids & Organs-on-Chips Asia 2022  |  Lab-on-a-Chip and Microfluidics Asia 2022  | 


2022年10月6日(木)

08:00

会議参加登録、資料受け取り、モーニングコーヒー&ティー


セッションタイトル: オープニングセッション -- フローケミストリーアジア2022

09:00

Paul Watts会議議長

アフリカにおける連続フロー医薬品製造
Paul Watts, Distinguished Professor and Research Chair, Nelson Mandela University, South Africa

While Africa has a variety of companies that formulate medicines it has very little active pharmaceutical ingredient (API) manufacturing, with the consequence that these need to be imported. This results in increased drug costs, making medications unaffordable to most patients in Africa.  Economic, social and political stresses have been witnessed all over the world during the COVID-19 pandemic. In particular, drug shortages and inaccessibility is one of the many results of disruption of supply chains due to the shutdown of manufacturing activity, as well as export restrictions and bans by other countries. To this effect, we are working on developing local drug manufacturing capacity in Africa using continuous flow technology, with the goal of lowering the cost of drugs, improving drug accessibility and ultimately improving Africa’s health. A selection of examples will be presented.

09:30

超音波マイクロリアクターにおける乳化重合
Simon Kuhn, Professor, Department of Chemical Engineering, KU Leuven, Belgium

Polymeric dispersions have broad applications in adhesives, coatings, catalyst support, encapsulation, and drug delivery. One approach is the generation of miniemulsions (50nm<d<1000nm) and subsequent polymerization to synthesize polymer nanoparticles that can achieve the desired size and morphology for targeting a specific application. Ultrasonic microreactors have proven to be effective in the generation of miniemulsions, although with a high polydispersity (PDI > 0.3). To address this issue, an ultrasonic microreactor was developed, which enables the generation of a monodisperse miniemulsion (PDI < 0.3) to synthesize polymer nanoparticles. This ultrasonic microreactor consists of serpentine channels with a square cross-section of 1.2 mm in borosilicate glass with a piezoelectric plate transducer attached to one side. The miniemulsion created by the cavitation activity in the ultrasonic microreactor is then fed into a temperature controlled (75°C) coiled loop reactor for the continuous polymerization of monomer droplets. Specifically, we study the cross-linking polymerization of butyl methacrylate, for which the continuous phase is water with a surfactant (Lutensol AT50), and the dispersed phase consists of the monomer butyl methacrylate, the cross-linking agent ethyl glycol dimethacrylate, the costabilizer hexadecane and the thermal initiator AIBN. Preliminary results highlight the performance of the developed system. For a dispersed to continuous volumetric flow rate ratio of 1:4, residence time of 4 min at a US frequency and power of 47kHz and 15W, particles with a mean hydrodynamic diameter of 94 nm and PDI of 0.15 were obtained. The influence of the operating parameters (load power, frequency, surfactant concentration, flow rate ratio and residence time) on the size of the miniemulsion droplets and to control the final particle size will be discussed in detail.

10:00

フローケミストリーと反応工学-神経保護剤合成への応用
Darren Riley , Associate Professor, University of Pretoria , South Africa

The presentation will focus on the development of end-to-end flow-based synthetic routes to pharmaceuticals with a neurological focus and will include aspects of batch-flow hybridization and reaction engineering. Insight will also be given pertaining to the use of flow technology as a disruptive leap-frogging technology for the localization of pharmaceutical manufacturing in developing countries.

10:30

午前中のコーヒー&ティー、展示会場におけるネットワーキングイベント

11:00

Stoli ChemCSTRシリーズ 通常のケミストリーより優れた特性
Nikolay Cherkasov, Managing Director, Stoli Chem

Conventional flow reactors such as tubes and chips are excellent. Their scaling up, however, is difficult because fluid velocity determines residence time, pressure drop, and mixing/heat transfer. CSTRs, on the other hand, provide mixing independent of flow rates and could handle exothermic, multiphase, and reactions with solids. We discuss case studies where such capabilities improve process throughput and yield.

11:30

フローケミストリーの高度化・エレクトロニクス化
Thomas Wirth, Professor, Cardiff University, United Kingdom

The advantages of increased mixing of biphasic reaction mixtures in flow offers great potential compared to conventional flask techniques, especially when combined with microwave irradiation or phase transfer catalysis. The presentation will also illustrate that metal-catalyzed reactions and enzyme-promoted transformations can be performed advantageously in biphasic systems. The development of a microreactor for electrochemistry including several applications will be discussed.

12:00

展示ホールでのネットワーキング・ランチ -- 出展社訪問とポスター展示 --弁当の昼食


セッションタイトル フローケミストリーアジア2022--フローケミストリーの新たな潮流

14:00

化学酵素反応におけるプロセスの高度化
Rodrigo de Souza, Professor, Federal University of Rio De Janeiro, Brazil

Continuous-flow technology has arrived at the drug manufacturing companies in order to avoid waste of time and tries to make process chemistry more efficient. It allows the development of cascade reactions, combining different steps without the need of isolation and purification, in a cost effective way in terms of time and money. During the last years our group has focused efforts on the development of chemo and enzymatic methodologies towards the synthesis of fine chemicals, intermediates and final APIs, which are important for the chemical industry in Brazil. Several examples will be shown, some of them featuring cascade chemo-enzymatic reactions, on the synthesis of levetiracetam, ethambutol, crizotinib, donepezil, among others.

14:30

フローケミストリーにおける構造異性体のリアルタイムセンシングのためのAPPI-MS/MS-IMSアプローチの高度化
Maarten Honing, Professor, Maastricht University, M4I Institute Maastricht MultiModal Molecular Imaging, Netherlands

In this presentation, the potentials for the in-situ detection of structural isomers is discussed. Main attention will be given to a classical Diels-Alder reaction, which besides some particular “synthesis byproducts”, also leads to the formation of structural isomers with the same molecular mass. In classical on-line MS detection these two isomers are not detected. A novel approach, using the difference in fragmentation energies and ion mobility separation , reveal the structures of both isomers allowing to elucidate the reaction mechanisms underlying their formation.

15:00

特殊ペプチドのマイクロフロー合成
Shinichiro Fuse, Professor, Nagoya University, Japan

Amide bond formation via generation of highly electrophilic species was developed. Undesired reactions were successfully suppressed by using micro-flow technologies.  The developed approach was used for synthesis of specialty peptides.

15:30

午後のコーヒー&ティーブレイクと展示ホールでのネットワーキング

16:00

アフリカでの原薬製造の現地化を支援するフローベースのプロセス開発
Jenny-Lee Panayides, Principal Scientist and Research Group Leader, CSIR Biosciences South Africa, South Africa

The presentation will focus on the efforts to adopt flow technology in developing countries for the manufacture of active pharmaceutical ingredients. Case studies will highlight the development of a flow-based route to a non-steroidal anti-inflammatory drug and discuss recent efforts to develop an economical platform for controlling and automating flow equipment.

16:30

Shu Kobayashi基調講演

議題は後日発表
小林 修 東京大学 教授

17:00

Guangsheng Luo基調講演

マイクロリアクターにおける粒子調製の制御
Guangsheng Luo, Professor, Tsinghua University, China

Microreaction as a high promising technology for the preparation of particles is becoming more and more important, and great progresses have been made in recent years. The processes of micromixing and multiphase microdispersion are key technologies for the preparation of spherical and nanoparticles. In this presentation, some new developments of micromixing and microdispersion will be introduced. And then, the preparation of some functional and nanoparticles using these new technologies will be presented. Finally, the future development will be discussed briefly.

17:30

カンファレンス1日目プログラム終了

2022年10月7日(金)

08:00

展示ホールでのコーヒー&ティー、ネットワーキング

09:00

Tanja JunkersKeynote Presentation

It's a Machines World: 高分子合成の自動化における課題と可能性
Tanja Junkers, Professor, School of Chemistry, Polymer Reaction Design group, Monash University, Australia

Contemporary macromolecular chemistry has matured to a point where virtually any polymer structure can be synthesized via combinations of controlled polymerization approaches, post-polymerization modification and efficient ligation strategies. Still, often large hurdles have to be overcome to take the next step in research, that is being able to provide such complex materials reliably on significant scale for use in advanced applications. A solution to this problem is to make use of continuous flow synthesis techniques. Flow reactors are associated with high reproducibility, intrinsically simple reaction scale-up and improved product qualities due to significant reduction of side reactions. Being an established method especially in the pharmaceutical chemistry domain, full potential with regards to macromolecular synthesis did not unfold until very recently. Among others, the benefits of using online-monitoring, reactor automation and machine-learning will be discussed and the development of fully autonomous based reactor systems presented. Also polymer self-assembly itself can largely benefit from flow operation, and first advances in this area will be presented. The potential of flow chemistry for preparative macromolecular chemistry will be discussed and explored on the example of polymerization. Further, the possibility to build reactor cascades and the advantages of online-monitoring will be highlighted. Machine-assisted synthesis of polymers is shown to be superior in accuracy in synthesis. Generally, the introduction of smart algorithms in synthesis control opens avenues into the digital chemistry space, and challenges and opportunities in this realm will be discussed.

09:30

放射化学におけるマイクロ流体工学とフローケミストリー:将来的に完璧な相性
Giancarlo Pascali, Professor, University of New South Wales, Australia

The use of microfluidic systems and flow chemistry was pioneered in radiochemistry in 2004; since then, numerous researchers have shown how using these techniques can provide a much better yield, economy, reliability and safety. This talk will give several examples demonstrating how the unique features of these approaches are a perfect match with the numerous challenges of radiochemistry. However, currently only a small number of commercial synthetic systems adopt these concepts; the last part of this talk will be aimed at proposing some causes for this surprising fact, potentially stimulating useful synergies with the traditional pharmaceutical manufacturing actors.

10:00

Dong Pyo Kim基調講演

スケールアップ生産と自律的自己最適化のための新規マイクロ流体プラットフォーム
Dong Pyo Kim, Yonsan Chaired Professor, Pohang University of Science And Technology (POSTECH), Korea South

Flow chemistry in the confined microfluidic space enables easy up-scaling production at precise controlled conditions. In the talk, we show the assembly of 16 numbering-up 3D printed metal microreactor to render high productivity up to 20 g for 10 min operation of subsecond ultrafast chemistry. And, hexagon-shaped 3D printed polymer module of photomicroreactor with solar concentrator leaded to facile assembly into serial and radial reconfiguration for high throughput of synthesis. In addition, for scalable production of emulsions, compact 3D printed droplet generator was devised by array of 40 drop-makers with a 3D void geometry and a flow distributor, producing microgels and microparticles. Finally, we explore ultrafast flow chemistry by autonomous self-optimizing platform that accelerates the optimization and screening of complex chemistry.

10:30

午後のコーヒー&ティーブレイクと展示ホールでのネットワーキング

11:00

連続フロー式光化学:いつ、なぜ、どのように?
Michael Oelgemöller, Associate Professor, James Cook University, Australia

Continuous-flow photochemistry has sparked a remarkable renaissance in organic photochemistry, especially in academia. A major issue of continuous-flow studies has been their reproducibility, as improvised light sources and reactor materials significantly impact on performances. A commonly mentioned advantage of flow operation is also its superiority over batch processes in terms of light penetration and mass-transfer. However, this claim is misleading as most batch studies in academia are conducted in sub-standard setups. Industrial photochemical processes are also rarely conducted in batch and utilize advanced setups instead. The only real advantage of continuous-flow operation may thus be simply its convenience and the ability to conduct photochemical studies rapidly and easily. This presentation will clarify some of the exaggerated claims associated with continuous-flow photochemistry. It will also present current strategies used in industrial photochemistry to overcome light penetration and mass-transfer limitations. The presentation will also highlight the need for a standard, purpose-designed flow photoreactor that covers the entire photochemically relevant UVC to visible light range.

12:00

展示ホールでのネットワーキング・ランチ -- 出展社訪問とポスター展示 --弁当の昼食

14:00

議題は後日発表
Christian Hornung, Director of FloWorks, CSIRO, Australia

14:30

Amanda Evans基調講演

議題は後日発表
Amanda Evans, Scientist, Los Alamos National Laboratory, United States of America

15:00

連続フロープロセス:材料と化学品製造のためのプロセス強化の新しいパラダイム
Anil Kumar, Professor, Indian Institute of Technology Bombay, India

Continuous flow process provides a potential alternative to batch synthesis because of its inherent advantages such as very efficient heat exchange, high batch to batch reproducibility, fast mixing, high throughput, safety, and the ability to do multistep telescoping synthesis.  Due to these advantages, these processes have been referred to as the most promising “Green Technology”. In fact, continuous flow processes are projected to be the “CHEMICAL FACTORIES” of tomorrow. Continuous flow processes also provide an “On-Demand” synthesis with complete control over reproducibility, size, shape and these parameters can be achieved at various scales (lab synthesis to pilot to bulk production) with excellent reproducibility. This opens up the opportunity for synthetic chemists to prepare materials with precise control over critical molecular design parameters. It also enables one to carry out material synthesis at higher temperatures that were outside the domain of an organic synthetic lab. We have been exploring continuous flow processes for the synthesis of conjugated polymers, nanoparticles and nanofibers, fine chemicals, catalysis for heterogeneous processes etc. In this presentation, I will review some of the recent advances in these directions and some results from our laboratory.


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