
Cambridge Healthtech Instituteのトレーニングセミナーでは、学術的な理論や背景を幅広くカバーするとともに、実際のケーススタディ、遭遇した問題、適用されたソリューションを提供します。各トレーニングセミナーでは、正式な講義とインタラクティブなディスカッションやアクティビティを組み合わせて、学習体験を最大化することができます。トレーニングセミナーは、経験豊富なインストラクターが担当し、現在の研究に応用可能なコンテンツに焦点を当てて、この分野に不慣れな方にも重要なガイダンスを提供します。
2023年11月14日(火) 08:25 - 18:30
TS7A: Introduction to Machine Learning for Biologics Design
TS7A:バイオ医薬品設計向け機械学習入門
Seminar Highlights:
- Basics of machine learning and where it fits into drug discovery
- Machine learning: a historical view of its application in the field of drug discovery
- How machine learning revolutionized homology modeling
- Applying machine learning to structure-based biologics design
- Guiding the design of display libraries using machine learning
INSTRUCTOR BIOGRAPHIES:
Christopher R. Corbeil, PhD, Research Officer, Human Health Therapeutics, National Research Council Canada
TS8A: Introduction to Bispecific Antibodies: History, Engineering, and Application
TS8A:二重特異性抗体入門:歴史、エンジニアリング、応用
Introduction to Bispecific Antibodies will be organized as an informative and practical guide to getting up to speed on critical aspects of bispecific antibody therapeutics. Topics will include historical successes, failures, and lessons learned. Specific practical instruction will span mechanisms of action, engineering, developability, regulatory considerations, and translational guidelines. Perspectives on ideal implementation of bispecifics as targeted and immunomodulatory approaches will be discussed.
Topics to be Covered:
- A brief history of bispecific antibodies: 60 years of progress with critical advances and key pioneers
- Bispecific applications and powerful mechanisms-of-action
- Engineering bispecific antibodies:100 formats and counting
- Bispecific-specific considerations in preclinical development and regulatory landscape
- Developability, manufacturing, and analytical considerations
- Clinical experience, translation, and regulatory approval
- Current trends and future opportunities in regulating immune checkpoints, cell-based therapies, and personalized approaches
INSTRUCTOR BIOGRAPHIES:
G. Jonah Rainey, PhD, Senior Director, Protein Engineering, Eli Lilly and Company
TS9A: Introduction to Protein Engineering
TS9A:タンパク質工学入門
Topics to be covered include:
What Is Protein Engineering?
- Functions amenable to engineering: affinity, specificity, catalysis, stability, solubility, immunogenicity, serum half-life
Tools and Techniques
- The measure of success: functional assays
- Engineering by design
- Engineering by random mutation
- Designed libraries display technologies
- Deep sequencing applications in analyzing libraries and repertoires
Production and Manufacturing
- Evaluating biotherapeutic developability
- Improving manufacturing by protein engineering methods
- Glycosylation engineering - function and homogeneity
- Other protein modifications
- Immunogenicity engineering and humanization
- Expression of antibodies and fragments for discovery and testing
- Manufacturing platforms for antibodies and fragments
Emerging Molecule and Product Formats
- Bispecific antibodies/binders
- Antibody-drug conjugates (ADCs)
- CAR T strategies
- Other emerging constructs
The Future of Protein Engineering
INSTRUCTOR BIOGRAPHIES:
David Bramhill, PhD, Founder, Bramhill Biological Consulting LLC
Training Seminar Information
Though CHI encourages track hopping between conference programs, we ask that Training Seminars not be disturbed once they have begun. In the interest of maintaining the highest quality learning environment for Training Seminar attendees, and because seminars are conducted differently than conference programming, we ask that attendees commit to attending the entire program, and not engage in track hopping, as to not disturb the hands-on style instruction being offered to the other participants.
* 不測の事態により、事前の予告なしにプログラムが変更される場合があります。
Conference Programs


- Antibody-Based Therapies
治療用抗体 - Emerging Targets & Approaches
新興の標的と治療アプローチ - Membrane Protein Targets
膜タンパク質の標的

- Safety & Efficacy of Bispecifics
二重特異性抗体の安全性と有効性 - Advancing Bispecifics
二重特異性の進歩 - Engineering Bispecifics
二重特異性の工学


- Optimisation & Developability
最適化と開発可能性 - Analytical Characterisation
アナリティクス特性評価 - Protein Stability & Formulation
タンパク質の安定性と製剤


