Main Conference - Day 3 (May 14)
6:45am - 7:45am60 mins
Sunrise Yoga
Sunrise Yoga: Wellness Event - Reservation Required
7:15am - 7:45am30 mins
Registration
Registration
Breakfast Spotlight Presentations
7:45am - 8:15am30 mins
Breakfast Spotlight Presentations 1
LNP-production for mRNA-vaccines, Therapeutics and for Gene-editing - Proof of Concept for a Versatile Process
- Thomas Vrucina - Deputy Head Liposome Technology, Polymun Scientific
Case Studies of Preclinical and Clinical Oligonucleotides in Development
8:25am - 8:30am5 mins
Oligonucleotide Discovery, Preclinical and Clinical
Chairwoman’s Remarks: Oligonucleotides for CNS Diseases
8:25am - 8:30am5 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Chairman’s Remarks: Oligonucleotide Analytics & Regulatory Perspectives
8:25am - 8:30am5 mins
Peptide Discovery to CMC
Co-Chairs' Remarks: Peptide CMC Strategies
8:25am - 8:30am5 mins
Genome Editing Technology and Applications
Co-Chairs': Genome Editing Preclinical and Clinical Updates: Part 1
8:25am - 8:30am5 mins
Delivery of Macromolecules
Chairman’s Remarks: Oligonucleotide Delivery Strategies
8:30am - 9:00am30 mins
Oligonucleotide Discovery, Preclinical and Clinical
TRiM™ Platform for Delivery of RNAi Therapeutics to the Central Nervous System via Subcutaneous Administration
8:30am - 9:00am30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Differentiation of n-1 Positional Isomers in Antisense Oligonucleotides with Orthogonal Mass Spectrometry Methods
8:30am - 9:00am30 mins
Peptide Discovery to CMC
Industry Perspective on the Selection of Regulatory Starting Materials for Synthetic Peptides
8:30am - 9:00am30 mins
Genome Editing Technology and Applications
Writing DNA with RNA: Genome Engineering by Target-Primed Reverse Transcription
8:30am - 9:00am30 mins
Delivery of Macromolecules
Delivery of RNAs with Hydrophilic Nanoparticles and Immune Modulation
9:00am - 9:30am30 mins
Oligonucleotide Discovery, Preclinical and Clinical
Progress Towards Oligonucleotide Therapeutics for Prion Disease
9:00am - 9:30am30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
sgRNA Single Nucleotide Resolution by Ion-pairing Reversed Phase Chromatography
9:00am - 9:30am30 mins
Peptide Discovery to CMC
Synthetic Peptide Enantiomeric Purity Analysis by Chiral HPLC-MS
9:00am - 9:30am30 mins
Genome Editing Technology and Applications
Expanding RNA Editing Applications to CNS Disorders Through AIMer Chemistry Design
9:00am - 9:30am30 mins
Delivery of Macromolecules
The Endosomal Escape Vehicle Platform Safely and Effectively Delivers Oligonucleotide Therapeutics to Skeletal and Cardiac Muscle Tissue for the potential treatment of Duchenne Muscular Dystrophy
9:30am - 10:00am30 mins
Oligonucleotide Discovery, Preclinical and Clinical
Antisense Oligonucleotides for the Treatment of Neurological Disease
9:30am - 10:00am30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Comparing Analytical Strategies for Diastereomer Profiling of a Fully Thiolated ASO
9:30am - 10:00am30 mins
Peptide Discovery to CMC
Challenges and Strategies in Managing Peptide Aggregation
9:30am - 10:00am30 mins
Genome Editing Technology and Applications
Prime Editors to Treat Human Liver and Metabolic Diseases
9:30am - 10:00am30 mins
Delivery of Macromolecules
Advancing Therapeutics with Antibody-Oligonucleotide Conjugates: Clinical Progress in Rare Muscle Diseases and Emerging Applications in Precision Cardiology
10:00am - 10:45am45 mins
Networking Refreshment Break in Poster and Exhibit Hall
10:45am - 11:15am30 mins
Oligonucleotide Discovery, Preclinical and Clinical
Divalent siRNAs as Novel Therapeutics for CNS Indications
10:45am - 11:15am30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
QC Method Development & Duplex Stability Analysis of siRNAs
10:45am - 11:15am30 mins
Peptide Discovery to CMC
Bioproduction Platform to Generate Functionalized Disulfide-constrained Peptide Analogues
10:45am - 11:15am30 mins
Genome Editing Technology and Applications
In Vivo Editing of HBG1/2 Promoters Leads to Fetal Hemoglobin Reactivation in Humanized Mouse Model
10:45am - 11:15am30 mins
Delivery of Macromolecules
VECTrans® Platform Achieves Efficient Functional Delivery of Oligonucleotides to the deep brain in NHP at Minimal Systemic Dose
11:15am - 11:45am30 mins
Oligonucleotide Discovery, Preclinical and Clinical
Intrathecal Delivery of Antisense Oligonucleotides for Treatment of a Genetic Form of Epilepsy
11:15am - 11:45am30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Regulatory Feedback on Late-stage Programs - A CDMO Perspective
11:15am - 11:45am30 mins
Peptide Discovery to CMC
Peptide Synthesis by Molecular Hiving
11:15am - 11:45am30 mins
Genome Editing Technology and Applications
Harnessing Endogenous ADAR for Oligo-Directed RNA Editing
11:15am - 11:45am30 mins
Delivery of Macromolecules
Safety, Tolerability and Activity of ABX1100, A CD71 Centyrin siRNA Conjugate Targeting GYS1 in a Phase 1 Study in Normal Healthy Volunteers
11:45am - 12:15pm30 mins
Oligonucleotide Discovery, Preclinical and Clinical
Mivelsiran, The First Investigational RNAi Therapeutic in Development for Alzheimer’s Disease, Bench to Bedside
11:45am - 12:15pm30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
A Unified Platform for the Online Determination of Multiple mRNA Quality Attributes
11:45am - 12:15pm30 mins
Peptide Discovery to CMC
CMC of Helicons™ - Helically Constrained Cell Permeable Peptides
11:45am - 12:15pm30 mins
Genome Editing Technology and Applications
Building a Best-in-class RNA Editing Platform for the Treatment of Genetic Diseases
11:45am - 12:15pm30 mins
Delivery of Macromolecules
Placental Delivery of Novel Lipid Conjugated siRNA for Treatment of Preeclampsia
12:15pm - 12:20pm5 mins
Oligonucleotide Discovery, Preclinical and Clinical
Transition to Spotlight Presentation Rooms
12:15pm - 12:20pm5 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Transition to Spotlight Presentation Rooms
12:15pm - 12:20pm5 mins
Peptide Discovery to CMC
Transition to Spotlight Presentation Rooms
12:15pm - 12:20pm5 mins
Genome Editing Technology and Applications
Transition to Spotlight Presentation Rooms
12:15pm - 12:20pm5 mins
Delivery of Macromolecules
Transition to Spotlight Presentation Rooms
12:20pm - 12:50pm30 mins
Spotlight Presentation 1
Tagging the Future: Scalable Biopolymer Production in Solution
- Matteo Villain, PhD - Vice President of Peptide and Oligonucleotide, Veranova
12:20pm - 12:50pm30 mins
Spotlight Presentation 4
Revolutionizing Gene Therapy through Non-Viral, Tissue-Selective Delivery Platforms
- Joo-Sung Yang - VP and Head of the New Therapeutics Business Development, Samyang Biopharm
12:20pm - 12:50pm30 mins
Spotlight Presentation 5
Efficient Conformational Sampling in Nucleic Acids Using LowModeMD
- Alain Deschênes - Vice President, Chemical Computing Group
12:50pm - 1:55pm65 mins
Networking Luncheon in Poster and Exhibit Hall
Networking Luncheon with Last Chance for Poster & Exhibit Viewing
1:10pm - 1:20pm10 mins
TIDES Talks in Poster and Exhibit Hall
Accelerating the GLP-1 Revolution: Process Technologies Enabling the Future of Peptide Therapeutics
1:20pm - 1:30pm10 mins
TIDES Talks in Poster and Exhibit Hall
Innovative Peptide Manufacturing: Piramal Pharma Solutions and the Power of Fragment Condensation to Overcome Resin Aggregation Challenges
1:55pm - 2:00pm5 mins
Oligonucleotide Discovery, Preclinical and Clinical
Chairman’s Remarks: Oligonucleotide Discovery to Clinic Case Studies
1:55pm - 2:00pm5 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Chairman’s Remarks: Innovations in Oligonucleotide Process Development and Manufacturing
1:55pm - 2:00pm5 mins
Peptide Discovery to CMC
Co-Chairs' Remarks: GLP-1 and Beyond: Peptide Therapeutics for Diabetes and Obesity/Oral Peptide and Novel Peptide Delivery Technologies
1:55pm - 2:00pm5 mins
Genome Editing Technology and Applications
Chairman’s Remarks: Genome Editing Preclinical and Clinical Updates: Part 2
2:00pm - 2:30pm30 mins
Oligonucleotide Discovery, Preclinical and Clinical
Delivering the Promise of RNAi to Extra-hepatic Tissues
2:00pm - 2:30pm30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Step Changes Towards Continuous Oligonucleotide Manufacturing
2:00pm - 2:30pm30 mins
Peptide Discovery to CMC
Fragment-Based Approaches for the Production of Peptide-based Therapeutics for Diabetes and Obesity
2:00pm - 2:30pm30 mins
Genome Editing Technology and Applications
Advancing Axiomer ADAR RNA Editing Platform: Therapeutic Applications and Progress Towards Clinical Development
2:30pm - 3:00pm30 mins
Oligonucleotide Discovery, Preclinical and Clinical
Correcting Aberrant Splicing of UNC13A As a Treatment for People with ALS
2:30pm - 3:00pm30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Preparation of Anti-Sense Oligonucleotide (ASO) via Hybrid Synthesis
2:30pm - 3:00pm30 mins
Peptide Discovery to CMC
Advancing Next-Generation Therapies for Obesity and Related Conditions
2:30pm - 3:00pm30 mins
Genome Editing Technology and Applications
AI-Guided Metagenomic Discovery of Compact CRISPR Systems for In Vivo Therapeutic Genome Editing
3:00pm - 3:30pm30 mins
Oligonucleotide Discovery, Preclinical and Clinical
Extending Oligonucleotide Delivery and Gene Knockdown to Specific Cell Types in Kidney
3:00pm - 3:30pm30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Next Generation Manufacturing Process for siRNA
3:00pm - 3:30pm30 mins
Peptide Discovery to CMC
Ultra Long-acting Anti-obesity Peptides
3:00pm - 3:30pm30 mins
Genome Editing Technology and Applications
LNP Delivery of AsCas12a Enables Liver Editing and Disease-Associated Protein/Biomarker Reduction for Multiple Targets in Mouse and Non-human Primate Preclinical Models
3:30pm - 4:00pm30 mins
Networking Refreshment Break
4:00pm - 4:30pm30 mins
Oligonucleotide Discovery, Preclinical and Clinical
FORCE(TM) Platform Enables TfR1-mediated Delivery of Therapeutics for Rare Neuromuscular Diseases
4:00pm - 4:30pm30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Solvent and Reagent in-situ Reuse in Solid Phase Oligonucleotide Synthesis
4:00pm - 4:30pm30 mins
Peptide Discovery to CMC
BIONDD™ [BEYOND] - Oral Delivery of Biologics with Bioavailability Similar to Subcutaneous Administration
4:00pm - 4:30pm30 mins
Genome Editing Technology and Applications
The Therapeutic Application of In Vivo CRISPR Gene Editing
4:30pm - 5:00pm30 mins
Oligonucleotide Discovery, Preclinical and Clinical
INHBE Silencing in Mice Confirms Human Genetic Data and Supports a New Approach for Obesity
4:30pm - 5:00pm30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
Multicolumn, Continuous Chromatography for Oligonucleotides
4:30pm - 5:00pm30 mins
Peptide Discovery to CMC
Universal Formulation for Oral Therapeutics As a Cornerstone of Improved Patient Care
4:30pm - 5:00pm30 mins
Genome Editing Technology and Applications
Single-course Gene Editing to Durably Lower Harmful Cholesterol
5:00pm - 5:30pm30 mins
Oligonucleotide Discovery, Preclinical and Clinical
Using the iNeuroRx® Technology Platform to Develop Disease-Modifying Treatments for ALS and FTD
5:00pm - 5:30pm30 mins
Oligonucleotide Chemistry, Manufacturing and Controls
ISPE Baseline Guide for Oligonucleotide Facility Design
5:00pm - 5:05pm5 mins
Peptide Discovery to CMC
Close of Peptide Track. Please Choose Another Session
5:00pm - 5:30pm30 mins
Genome Editing Technology and Applications
Tune-401: a First-in-class Epigenetic Silencer Developed for the Treatment of Chronic Hepatitis B
5:30pm - 5:35pm5 mins
Close of TIDES 2025
* 不測の事態により、事前の予告なしにプログラムが変更される場合があります。