2026年トレーニングセミナー（対面のみ）

*プレミアム価格または別途登録が必要

Cambridge Healthtech Instituteのトレーニングセミナーでは、実際のケーススタディ、遭遇した問題、適用されたソリューションのほか、学術的な理論と背景に関する幅広い説明を提供します。各トレーニングセミナーでは、正式な講義とインタラクティブなディスカッションやアクティビティを組み合わせて、学習体験を最大限に高めることができます。これらのトレーニングセミナーでは、経験豊富な講師が、現在の研究に適用可能な内容に焦点を当て、その分野の初心者に重要なガイダンスを提供します。

Drug Discovery Chemistryによるトレーニングセミナーは、対面のみで提供されます。

Monday, April 13, 2026 10:00 am - 5:15 pm

TS1: Drug Exposure at the Target: The Role of ADME and Pharmacokinetics

This training seminar describes how pharmacokinetics (PK) affects drug exposure at the intended target. The seminar opens with a foundation of clinical PK including the determination of key PK parameters from Cp-time data. Course materials also cover common preclinical ADME assays that allow estimation of a compound’s human PK properties. The materials bridge the idea of a compound’s PK and its observed pharmacodynamic effects (PD) through coverage of PK/PD modeling. Various drug modalities (e.g., small molecules, antibodies, and peptides) illustrate the concepts of the course.

Session 1:

Determining PK parameters from Cp-time data
ADME & membrane permeability
Plasma protein binding & metabolic stability

Session 2:

Compartment models & PBPK
Drug modalities & formulation
PK/PD models

This course is designed for:

Scientists and researchers in drug discovery or development who want a stronger grasp of how PK and ADME data impact efficacy and safety.
Graduate students or postdocs in pharmacology, medicinal chemistry, or pharmaceutical sciences looking to build real-world context around their training.
Regulatory professionals seeking to better understand how PK data are generated and interpreted.
Project managers or non-specialists involved in cross-functional teams who need a working knowledge of PK to facilitate communication and strategy.

Why attend?

Understanding drug exposure is essential for developing successful therapies. This seminar bridges theoretical PK concepts with practical applications in preclinical and clinical development, helping attendees contribute more effectively to research and decision-making in their organizations.

INSTRUCTOR BIOGRAPHIES:

Erland Stevens, PhD, James G. Martin Professor, Department of Chemistry, Davidson College

Erland Stevens is formally trained as a synthetic organic chemist, with a PhD from the Department of Chemistry at the University of Michigan at Ann Arbor. He specialized in nitrogen heterocycle synthetic methodology. After completing his postdoctoral research at The Scripps Research Institute in La Jolla, CA, he joined the chemistry faculty at Davidson College in Davidson, NC. In addition to teaching organic chemistry, he created an undergraduate medicinal chemistry course and later published a textbook, Medicinal Chemistry: The Modern Drug Discovery Process, with Pearson Education. He then created an online medicinal chemistry course, which has been continuously revised and publicly available for approximately 10 years. He subsequently worked with Novartis to create additional online materials that are used with employees for continuing education purposes. He maintains an interest in the computational prediction of pharmacokinetic parameters based on structural features of drug-like structures.

*不測の事態により、事前の予告なしにプログラムが変更される場合があります。

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