2024年度のショートコース
Check back in June for 2025 short courses. All short courses take place in-person only!
Monday, 4 November, 2024 14:00 - 17:00
SC1: Developability of Bispecific Antibodies: Formats and Applications
Bispecific antibodies are a rapidly growing and clinically validated class of antibodies with marketed drugs and multiple candidates in clinical trials. Targeting multiple antigens in a synergistic manner can confer enhanced therapeutic benefit and potentially uncover novel biological mechanisms. However, multiple formats and a tedious candidate selection process to select functional and developable bispecific antibodies makes such programs cumbersome. This short course highlights the rapid growth in the field, therapeutic applications, and focuses on challenges with discovery and development of bispecific antibodies. We will use an approved bispecific antibody as a case study to understand the varied aspects of discovery and development of bispecific antibody programs.
Nimish Gera, PhD, Vice President, Biologics, Mythic Therapeutics
SC2: Advanced Applications of SPR & BLI Biosensors for Drug Discovery and Development
The surface plasmon resonance (SPR) and bio-layer interferometry (BLI) biosensors stand as the cornerstone real-time label-free (RT-LF) platforms for characterizing protein-protein interactions. Traditionally used for determining critical antibody binding affinities in lead therapeutic molecule selection, these biosensors now face evolving demands. With advancements in protein engineering and regulatory agencies mandating deeper elucidation of mechanism of action, there is a continued need to design sophisticated SPR and BLI assays. This short course aims to unveil novel approaches in designing SPR/BLI assays that emulate biological processes on the chip, along with the challenges encountered in their development. Various assays instrumental in identifying multiple clinical molecules will be showcased, highlighting the importance of SPR/BLI assays. Innovative assays tailored specifically for assessing the mechanism of action of clinical candidates which has become an integral part of the IND filing process, will also be presented. Attendees will gain valuable insights into harnessing these cutting-edge techniques to bolster their research endeavors and regulatory submissions.
Vishal Kamat, PhD, Senior Director, Protein Sciences, Ampersand Biomedicines
SC3: Tools for Cell Line Engineering and Development
Where are we heading to? We are heading to the future of tools for Cell Line Engineering and Development. The first question we ask is "how early can we go to clinic"? Then, we move to look at landing pads—are they really the future? This course will also address genetic engineering and new biologics platforms.
Mario P. Pereira, PhD, Director of Technology & Business Development, ATUM
SC4: In silico and Machine Learning Tools for Antibody Design and Developability Predictions
In silico developability predictive platforms offer promising screening support to identify optimal properties of a candidate biotherapeutic at early stages. Predicting your biologic’s developability can help avoid instability problems during later development and impede significant economic consequences.
Rahmad Akbar, PhD, Senior Data Scientist, Antibody Design, Novo Nordisk
Philip M. Kim, PhD, Professor, Molecular Genetics & Computer Science, University of Toronto
Shipra Malhotra, PhD, Senior Scientist, Biologics, Computational Biology and Machine Learning, Takeda
SC5: Best Practices for Targeting GPCRs, Ion Channels, and Transporters with Monoclonal Antibodies
Complex membrane proteins are important therapeutic targets and together represent the majority of protein classes addressed by therapeutic drugs. Significant opportunities exist for targeting complex membrane proteins with antibodies, but it has been challenging to discover therapeutic antibodies against them. This course will examine emerging technologies and strategies for enabling the isolation of specific and functional antibodies against GPCRs, ion channels, and transporters, and highlight progress via case studies.
Ross Chambers, PhD, Vice President, Antibody Discovery, Integral Molecular, Inc.
SC6: Introduction to Immunogenicity of Biotherapeutics
This short course aims to provide foundation knowledge of biotherapeutics immunogenicity and immunogenicity risk assessment in the context of biotherapeutic drug development, covering topics such as:
• What is Immunogenicity
• Why do we care
• Health Agencies expectations
• Major components of the Immunogenicity Risk Assessment
• Objective of assigning an overall immunogenicity risk to a program
Sophie Tourdot, PhD, Immunogenicity Sciences Lead, BioMedicine Design, Pfizer
Maria-Dolores Vazquez-Abad, PhD, Vice President, Clinical Immunogenicity, Pfizer Inc.
* 不測の事態により、事前の予告なしにプログラムが変更される場合があります。
会議プログラム

工学ストリーム

ターゲットストリーム

二重特異性ストリーム

免疫療法ストリーム

分析法ストリーム
- Optimisation & Developability
最適化・開発可能性 - Analytical Characterisation
分析法の特性評価 - Protein Stability & Formulation
タンパク質の安定性・剤形

発現ストリーム

機械学習ストリーム
