Co-Located Conference AgendasFlow Chemistry Asia 2023 | 
2023年10月5日（木）08:00 | Conference Registration, Materials Pick-Up, Coffee and Tea in the Exhibit Hall
カンファレンス受付、資料受け取り | |
Session Title: Flow Chemistry Asia 2023 Opening Session
セッションタイトル：Flow Chemistry Asia 2023オープニングセッション |
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Session Chairperson: Professor Dr. Paul Watts, Nelson Mandela University
セッション議長：Paul Watts博士、ネルソンマンデラ大学教授 |
| | 09:00 |  | カンファレンス議長 Welcome and Introduction by Conference Co-Chairperson
カンファレンス議長による挨拶
Paul Watts, Distinguished Professor and Research Chair, Nelson Mandela University, South Africa
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| 09:15 |  | カンファレンス議長 Welcome and Introduction by Conference Co-Chairperson
カンファレンス議長による挨拶
Simon Kuhn, Professor, Department of Chemical Engineering, KU Leuven Belgium, Belgium
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| 09:30 |  | 基調プレゼンテーション Conference Opening Keynote -- Running Hazardous Chemistry in Flow - HF, F2, SF4 and More……
カンファレンスオープニング基調講演 -- フローにおけるハザードケミストリーの実行 - HF、F2、SF4、およびその他
C. Oliver Kappe, Professor and Scientific Director, Center for Continuous Flow Synthesis and Processing, University of Graz, Austria
Organofluorine compounds are gaining popularity in chemical industries, especially in pharma and agrochemistry. Approximately 50% of the blockbuster drugs contain fluorine atoms. Organofluorine blockbuster drugs include e.g. atorvastatin (cardiovascular diseases), dolutegravir (HIV), emtricitabine (HIV), enzalutamide (cancer), and sitagliptin (diabetes). The introduction of fluorine atoms considerably influences the physical, chemical and biological properties of organic compounds as the bioavailability, lipophilicity or the metabolic stability of pharmaceuticals can be improved remarkably. This ever-increasing demand has transformed fluorine chemistry into a rapidly growing field of research. Despite this strong demand for fluorinated molecules in the pharma and agrochemical industry, the production of fluorinated compounds is often outsourced to specialized laboratories. This is likely the result of safety concerns in handling hazardous fluorinating reagents, alongside lack of expertise and equipment. Continuous flow chemistry has become an established method to perform hazardous reactions in a safe and controlled manner. In this lecture, contributions from our research group in the field of handling hazardous fluorinating reagents under flow conditions will be highlighted. Emphasis will be given on the safe use of HF (as amine complex), F2 (10% F2 in N2) and SF4 towards the synthesis of APIs or advanced intermediates. |
| 10:15 |  | 基調プレゼンテーション Microfluidics, A Versatile Tool to Produce High Quality Nanomaterials in Continuous Flow
連続フローで高品質のナノマテリアルを生産するための多用途ツールであるマイクロ流体
Victor Sebastian, Full Professor, University of Zaragoza, Spain
In the last decade, the synthesis of nanomaterials with controlled size, shape and composition has received great interest due to their unique properties, enhancing their application in a plethora of fields: biomedicine, molecular diagnosis, biosensing, catalysis, energy, optics and electronics. Consequently, the controlled synthesis of nanomaterials has attracted significant attention because their properties are directly determined by their morphological and chemical features. However, there are urgent problems originated from very recent and practical demands in nanomaterial synthesis and the not straightforward scale-up of the successful laboratory-adapted protocols to an industrial level. This lecture will provide an overview of the adoption of microfluidic flow chemistry in the synthesis of inorganic, organic and hybrid nanomaterials. Microfluidics allows a novel process control window of well-defined nanomaterials, where the counterparts produced in conventional batch-type reactors are replicated but with an excellent control in size distribution, shape, and chemical composition. |
| 10:45 | Mid-Morning Coffee and Tea Break and Networking in the Exhibit Hall
休憩および展示ホールでのネットワーキング | 11:15 | Rapid and Column-Chromatography-Free Flow-Peptide Chain Elongation
迅速・カラムクロマトグラフィー不使用でのフローによるペプチド鎖伸長
Shinichiro Fuse, Professor, Nagoya University, Japan
Peptides have become increasingly important as drugs. In this study, we developed rapid, mild and column-free peptide chain elongation via one-flow, three-component coupling approach using amino acid N-carboxy anhydride (NCA) which has both nucleophilicity and electrophilicity. The key to success was the rapid generation of acid chloride from amino acid and its rapid coupling with NCA via rapid dual activation. | 11:45 | Rapid Formation of Multi-layer Microcapsule in Microflow
マイクロフローにおける多層マイクロカプセルの迅速な形成
Takaichi Watanabe, Research Associate Professor, Okayama University, Japan
We present formation of multi-layer microcapsules using a simple emulsion drop formed in microflow. | 12:15 |  | 基調プレゼンテーション New Opportunities for Flow Electrochemistry
フロー電気化学の新たな機会
Thomas Wirth, Professor, Cardiff University, United Kingdom
The development of a microreactor for electrochemistry including applications to modern synthesis will be discussed. The electrochemical generation of hypervalent iodine compounds using this technique will be highlighted in detail, together with examples of halogenations using such reagents. Reactions towards the formation of N-N-bonds will also be discussed. |
| 12:45 | Networking Luncheon in the Exhibit Hall -- Network with the Exhibitors, View Posters and Engage with Colleagues
展示ホールでのネットワーキングランチ -- 出展者や同業者との交流、ポスターの観覧 | |
Session Title: Engineering in Flow Chemistry, circa 2023
セッションタイトル：2023年頃のフローケミストリーにおけるエンジニアリング |
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Session Chairperson: Professor Dr. Simon Kuhn, KU Leuven
セッション議長：Simon Kuhn博士、ルーベンカトリック大学教授 |
| | 14:00 |  | 基調プレゼンテーション Process Intensification: Producing More with Less
プロセスの強化：より少ない投入による多くの生産
Daria Camilla Boffito, Canada Research Chair in Engineering Process Intensification and Catalysis (EPIC) and Associate Professor, Polytechnique Montreal, Canada
Economic growth while accounting for social needs, climate change and environmental protection are key to tackle the United Nations Sustainable Development Goals (UN-SDGs) and accelerate the energy transition towards the electrification of the chemical industry. Green technologies based on cleaner energy sources such as biofuels, hydroelectricity, wind and natural gas are a global priority. Their implementation cannot only rely on existing industrial infrastructures but needs new resources and space. This represents a limit to the increase in the production capacity of existing chemical plants and to the development of new technologies. Process Intensification (PI) is a new archetype of the chemical industry that targets order of magnitude improvements to manufacture chemicals by either retooling existing facilities or finding new smaller, more efficient breakthrough technologies. Examples of PI technologies include HiGee reactors (e.g. spinning-disc reactors), alternative energy vectors to power chemical processes (ultrasound, microwaves, plasma), static mixers, and membrane reactors. In this talk, Prof. Boffito will show how PI still struggles to find a definition, despite the undisputable advantages. These include, for instance, energy, capital and operational expenditures (CapEx and OpEx) savings in the 20-80% range, and a reduction of emitted CO2 eq. up to 80%. She will also explain how PI represents a paradigm-shift that, by a matter of fact will change the chemical industry in the upcoming years. Prof. Boffito will browse the available methods to intensify chemical processes, specifically those for carbon capture and utilization (CCU), and will explain why we need to apply them both to existing and new processes. Further, she will highlight how PI can contribute to attain the UN-SDGs. |
| 14:30 | Sustainable Chemical Synthesis of High Added-Value Compounds from Renewable Sources in Flow Regime
フローレジームにおける再生可能資源からの高付加価値化合物のサステナブルな化学合成
Julio Cezar Pastre, Associate Professor, University of Campinas - UNICAMP, Brazil
Raw materials from renewable sources, as well as agro-industrial waste, represent an attractive source of useful chemical functionalities. Our research group has already identified continuous flow processing as a fundamental technology for the valorization of such materials. Flow chemistry offers unique opportunities for the conversion of biomass derivatives into chemical compounds with higher-added value, since it brings numerous advantages in terms of unique process experience, scalability, and reduced environmental footprint. In this context, we will present our efforts for the synthesis of platform molecules (such as furanics) and new chemicals (monomers, nitrogenated aromatics) from biomass derivatives.
For some representative works, please see:
Marcon, H. M.; Pastre, J. C. “Continuous flow Meerwein-Ponndorf-Verley reduction of HMF and Furfural using basic zirconium carbonate”. RSC Advances 2022, 12, 7980-7989.
Galaverna, R.; Fernandes, L. P.; Browne, D. L.; Pastre, J. C. “Continuous Flow Processing as a Tool for the Generation of Terpene-Derived Monomer Libraries”. Reac. Chem. Eng. 2019, 4, 362-367.
Galaverna, R.; Ribessi, R. L.; Rohwedder, J. J. R.; Pastre, J. C. “Coupling Continuous Flow Microreactors to MicroNIR Spectroscopy: Ultra-Compact Device for the Facile In-line Reaction Monitoring”. Org. Process Res. Dev. 2018, 22, 780-788.
Galaverna, R.; Breitkreitz, M. C.; Pastre, J. C. “Conversion of D-Fructose to 5-(Hydroxymethyl)furfural: Evaluating Batch and Continuous Flow conditions by Design of Experiments and In-line FT-IR Monitoring”. ACS Sustainable Chem. Eng. 2018, 6, 4220-4230. | 15:00 | Fundamentals and Research Progress of Photochemical Microreaction Technology
マイクロ光化学反応技術の基礎と研究の進展
Yuanhai Su, Professor, Shanghai Jiao Tong University, China
The research progress of our group in photochemical microreaction technology will be introduced, focusing on the design and construction strategies of photomicroreactors and its applications in synthesis of high-value chemicals associated with mass transfer, reaction kinetics and automatic control studies. | 15:30 | Mid-Afternoon Coffee and Tea Break and Networking in the Exhibit Hall
休憩と展示ホールでのネットワーキング | 16:00 | Contributions of Reaction Engineering Towards Efficient Photochemical Processes
光化学プロセスの効率化に向けた反応工学の貢献
Dirk Ziegenbalg, Professor of Chemical Engineering, Ulm University, Germany
The contribution will discuss the fundamentals of photochemical reaction engineering in the context of comprehensive reporting and characterization of laboratory experimental setups. It will be shown that synergistic interdisciplinary work can lead to an enhanced photocatalytic performance through dynamic irradiation strategies, in-depth mechanistic understanding, and improved reactor designs. Examples will be provided to illustrate this point. | 16:30 |  | 基調プレゼンテーション Title to be Confirmed.
タイトル未定
Shu Kobayashi, Professor, The University of Tokyo, Japan
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| 17:00 | Process Intensification for the Electrification of Chemical Manufacturing
化学品製造の電化に向けたプロセスの強化
Simon Kuhn, Professor, Department of Chemical Engineering, KU Leuven Belgium, Belgium
Small scale flow reactors have great advantages over conventional reactors, such as well-controlled flow patterns and increased surface-to-volume ratios, resulting in enhanced heat and mass transfer rates. Coupled with other benefits such as inherent safety allowing to perform reactions at elevated temperatures, pressures, or using highly reactive intermediates, they have become an attractive choice for the continuous manufacturing of chemicals and pharmaceuticals. However, these applications are still hindered by two important obstacles namely, weak convective mixing and issues regarding solids handling. Integrating ultrasound with small scale flow reactors has proven to be one of the more promising methods to address these issues. With selected examples, we will showcase the synergistic effect of ultrasound for particle synthesis, as well as electro- and photochemical processes. Exploiting these synergistic effects results in novel reactor concepts which will support the shift in chemical manufacture towards green and sustainable processes based on renewable energy sources. | 17:30 | Networking Reception in the Exhibit Hall with Japanese Beer and Sake
展示ホールでのネットワーキングレセプション | 18:30 | Close of Day 1 Conference Programming
1日目カンファレンスプログラム終了 |
2023年10月6日（金）08:00 | Morning Coffee, Tea and Networking in the Exhibit Hall
展示ホールでのネットワーキング | |
Session Title: Photochemistry and Other Approaches Converging with Flow Chemistry
セッションタイトル：フローケミストリーと融合する光化学とその他のアプローチ |
| | 09:00 | New Organic Electrosynthetic Processes Innovated by Flow Reactor Technology
フロー反応技術による新たな有機電気合成プロセスの革新
Mahito Atobe, Professor, Graduate School of Science and Engineering, Yokohama National University, Japan
Organic electrosynthesis is expected to be a typical green chemistry process because it does not require any hazardous reagents and produces less waste than conventional chemical synthesis. In fact, a number of successful new green organic electrolytic processes have been developed to date. In addition, electrochemical methodologies based on new concepts have been also developed. These related studies have become an active research area. This presentation will outline a new organic electrosynthetic processes based on flow reactor technology, focusing on our research. | 09:30 | Ultrafast and Continuous Flow Synthesis of Zeolites
ゼオライトの超高速・連続フロー合成
Toru Wakihara, Professor, The University of Tokyo, Japan
Zeolites have typically been synthesized via hydrothermal treatment, a process designed to artificially mimic the geological formation conditions of natural zeolites. This synthesis route, typically carried out in batch reactors like autoclaves, takes a time so long (typically, on the order of days) that the crystallization of zeolites had long been believed to be very slow in nature. Long periods of hydrothermal treatment also cause a burden on both energy efficiency and operational costs. Recently, we have reported the ultrafast syntheses of a class of industrially important zeolites within several minutes. Further shortening the crystallization time to the order of seconds would be a great challenge but can significantly benefit the mass product of zeolites as well as the fundamental understanding of the crystallization mechanism. | 10:00 |  Triplex Plunger Driven Diaphragm Pumps
トリプレックスプランジャー型ダイヤフラムポンプ
Harayuki Morikawa, General Manager, Fuji Techno Industries Corporation
We will be presenting two new offers to our portfolio.
1st our newly developed diaphragm pump, which unlike others, can handle a vast majority of slurry liquids.
2nd our AI software which further minimizes pulsation thru AI learning of the pulsation patterns and adjusting the motor speed.
In the introduction, we will explain the operating principles, performance, benefits of our innovative products.
| 10:30 | Mid-Morning Coffee and Tea Break and Networking in the Exhibit Hall
休憩および展示ホールでのネットワーキング | 11:00 | Title to be Confirmed.
タイトル未定
Noah Malmstadt, Professor, Mork Family Dept. of Chemical Engineering & Materials Science, University of Southern California, United States of America
| 11:30 |  | 基調プレゼンテーション Gas-liquid Micro Dispersion and its Performance
気体-液体の微細分散とその性能
Guangsheng Luo, Professor, Tsinghua University, China
Gas-liquid process is one of the most common multiphase processes in chemical industry, and the environmental-friendly, high-effective, safe technology is always a chasing goal. The gas-liquid microreaction technology provides a new opportunity for the intensification of the gas-liquid process, and good gas-liquid microdispersion is the prerequisite for the excellent performance of the subsequent reaction process. Accordingly, this report concentrates on the progress of gas-liquid microdispersion technologies from the development of the microdevice structure and the enhancement of the microdispersion performance. A strategy that changes the gas kinetic energy to generate the desired bubble/liquid slug size and gas-liquid flow regime is proposed to generate the Taylor bubble flow, bubbly flow, and short bubble flow. Besides, by embedding a capillary in the gas channel and introducing a step structure to the liquid channel, the bubble size can easily break through the restriction of microchannel size and can be reduced to 25% of the microchannel size, and the aspect ratio of the Taylor bubble can break through the critical value of 1.0 and be reduced to 0.5. Importantly, the mass transfer specific surface area in the novel gas-liquid microdispersion device is higher up to 10400 m2/m3 and the liquid-side mass transfer coefficient could be larger up to 60×10-4 m/s, which has increased by 30% and 5-9 times compared with the best level in the conventional T-junction microchannel, respectively. Finally, the direction of the gas-liquid microdispersion technology is pointed out. |
| 12:15 | Networking Luncheon in the Exhibit Hall -- Network with the Exhibitors, View Posters and Engage with Colleagues
展示ホールでのネットワーキングランチ -- 出展者や同業者との交流、ポスターの観覧 | |
Session Title: Emerging Trends and New Advances in the Flow Chemistry Ecosystem
セッションタイトル：フローケミストリーのエコシステムにおける新たな動向と進展 |
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タイトル未定
Shusaku Asano, Assistant Professor, Kyushu University, Japan
| 14:30 | Continuous Flow Hydrogenations for the Chemical Manufacturing Industry
化学品製造産業のための連続フロー水素化
Christian Hornung, Research Group Leader, CSIRO, Australia
Our group at CSIRO has developed a new structured catalyst reactor system, termed Catalytic Static Mixers or CSMs, which is based on 3D printed metal scaffolds coated with a noble metal catalyst such as Pt, Pd, Ni, Ru or others. These tubular reactors are used in continuous flow hydrogenations for the chemical manufacturing industry as well as for hydrogen reforming on demand. With the help of computational fluid dynamics, the structure of the mixer lattice can be optimised for a range of different outputs, such as minimised pressure drop, maximised heat transfer or optimised mixing. CSMs can be classified as a hierarchical catalyst system, whereby different length scales are addressed by different preparation methods; cm-, mm- and µm-scale features are formed by the 3D printing process and classical engineering design while certain µm- and nm-scale features are created during the catalyst preparation and deposition procedures. This results in a highly efficient and versatile catalyst platform which can be used in a broad range of different applications including homogeneous liquid phase, emulsion, liquid-gas and gas phase processes. | 15:00 |  | 基調プレゼンテーション Title to be Confirmed.
タイトル未定
Volker Hessel, Professor, School of Chemical Engineering, The University of Adelaide, Australia
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| 15:30 | Mid-Afternoon Coffee Break and Networking in the Exhibit Hall
休憩と展示ホールでのネットワーキング | 16:00 | Title to be Confirmed.
タイトル未定
Anil Kumar, Professor, Indian Institute of Technology Bombay, India
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* 不測の事態により、事前の予告なしにプログラムが変更される場合があります。
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