SELECTBIO Conferences Flow Chemistry Asia 2023


Co-Located Conference Agendas

Flow Chemistry Asia 2023 | 



Conference Registration, Materials Pick-Up, Coffee and Tea in the Exhibit Hall

Session Title: Flow Chemistry Asia 2023 Opening Session
セッションタイトル:Flow Chemistry Asia 2023オープニングセッション

Session Chairperson: Professor Dr. Paul Watts, Nelson Mandela University
セッション議長:Paul Watts博士、ネルソンマンデラ大学教授


Paul Wattsカンファレンス議長

Welcome and Introduction by Conference Co-Chairperson

Paul Watts, Distinguished Professor and Research Chair, Nelson Mandela University, South Africa


Simon Kuhnカンファレンス議長

Welcome and Introduction by Conference Co-Chairperson

Simon Kuhn, Professor, Department of Chemical Engineering, KU Leuven Belgium, Belgium


C. Oliver Kappe基調プレゼンテーション

Conference Opening Keynote -- Running Hazardous Chemistry in Flow - HF, F2, SF4 and More……
カンファレンスオープニング基調講演 -- フローにおけるハザードケミストリーの実行 - HF、F2、SF4、およびその他

C. Oliver Kappe, Professor and Scientific Director, Center for Continuous Flow Synthesis and Processing, University of Graz, Austria

Organofluorine compounds are gaining popularity in chemical industries, especially in pharma and agrochemistry. Approximately 50% of the blockbuster drugs contain fluorine atoms. Organofluorine blockbuster drugs include e.g. atorvastatin (cardiovascular diseases), dolutegravir (HIV), emtricitabine (HIV), enzalutamide (cancer), and sitagliptin (diabetes). The introduction of fluorine atoms considerably influences the physical, chemical and biological properties of organic compounds as the bioavailability, lipophilicity or the metabolic stability of pharmaceuticals can be improved remarkably. This ever-increasing demand has transformed fluorine chemistry into a rapidly growing field of research. Despite this strong demand for fluorinated molecules in the pharma and agrochemical industry, the production of fluorinated compounds is often outsourced to specialized laboratories. This is likely the result of safety concerns in handling hazardous fluorinating reagents, alongside lack of expertise and equipment. Continuous flow chemistry has become an established method to perform hazardous reactions in a safe and controlled manner. In this lecture, contributions from our research group in the field of handling hazardous fluorinating reagents under flow conditions will be highlighted. Emphasis will be given on the safe use of HF (as amine complex), F2 (10% F2 in N2) and SF4 towards the synthesis of APIs or advanced intermediates.


Victor Sebastian基調プレゼンテーション

Microfluidics, A Versatile Tool to Produce High Quality Nanomaterials in Continuous Flow

Victor Sebastian, Full Professor, University of Zaragoza, Spain

In the last decade, the synthesis of nanomaterials with controlled size, shape and composition has received great interest due to their unique properties, enhancing their application in a plethora of fields: biomedicine, molecular diagnosis, biosensing, catalysis, energy, optics and electronics. Consequently, the controlled synthesis of nanomaterials has attracted significant attention because their properties are directly determined by their morphological and chemical features. However, there are urgent problems originated from very recent and practical demands in nanomaterial synthesis and the not straightforward scale-up of the successful laboratory-adapted protocols to an industrial level. This lecture will provide an overview of the adoption of microfluidic flow chemistry in the synthesis of inorganic, organic and hybrid nanomaterials. Microfluidics allows a novel process control window of well-defined nanomaterials, where the counterparts produced in conventional batch-type reactors are replicated but with an excellent control in size distribution, shape, and chemical composition.


Mid-Morning Coffee and Tea Break and Networking in the Exhibit Hall


Rapid and Column-Chromatography-Free Flow-Peptide Chain Elongation

Shinichiro Fuse, Professor, Nagoya University, Japan

Peptides have become increasingly important as drugs. In this study, we developed rapid, mild and column-free peptide chain elongation via one-flow, three-component coupling approach using amino acid N-carboxy anhydride (NCA) which has both nucleophilicity and electrophilicity. The key to success was the rapid generation of acid chloride from amino acid and its rapid coupling with NCA via rapid dual activation.


Rapid Formation of Multi-layer Microcapsule in Microflow

Takaichi Watanabe, Research Associate Professor, Okayama University, Japan

We present formation of multi-layer microcapsules using a simple emulsion drop formed in microflow.


Thomas Wirth基調プレゼンテーション

New Opportunities for Flow Electrochemistry

Thomas Wirth, Professor, Cardiff University, United Kingdom

The development of a microreactor for electrochemistry including applications to modern synthesis will be discussed. The electrochemical generation of hypervalent iodine compounds using this technique will be highlighted in detail, together with examples of halogenations using such reagents. Reactions towards the formation of N-N-bonds will also be discussed.


Networking Luncheon in the Exhibit Hall -- Network with the Exhibitors, View Posters and Engage with Colleagues
展示ホールでのネットワーキングランチ -- 出展者や同業者との交流、ポスターの観覧

Session Title: Engineering in Flow Chemistry, circa 2023

Session Chairperson: Professor Dr. Simon Kuhn, KU Leuven
セッション議長:Simon Kuhn博士、ルーベンカトリック大学教授


Daria Camilla Boffito基調プレゼンテーション

Process Intensification: Producing More with Less

Daria Camilla Boffito, Canada Research Chair in Engineering Process Intensification and Catalysis (EPIC) and Associate Professor, Polytechnique Montreal, Canada

Economic growth while accounting for social needs, climate change and environmental protection are key to tackle the United Nations Sustainable Development Goals (UN-SDGs) and accelerate the energy transition towards the electrification of the chemical industry. Green technologies based on cleaner energy sources such as biofuels, hydroelectricity, wind and natural gas are a global priority. Their implementation cannot only rely on existing industrial infrastructures but needs new resources and space. This represents a limit to the increase in the production capacity of existing chemical plants and to the development of new technologies. Process Intensification (PI) is a new archetype of the chemical industry that targets order of magnitude improvements to manufacture chemicals by either retooling existing facilities or finding new smaller, more efficient breakthrough technologies. Examples of PI technologies include HiGee reactors (e.g. spinning-disc reactors), alternative energy vectors to power chemical processes (ultrasound, microwaves, plasma), static mixers, and membrane reactors. In this talk, Prof. Boffito will show how PI still struggles to find a definition, despite the undisputable advantages. These include, for instance, energy, capital and operational expenditures (CapEx and OpEx) savings in the 20-80% range, and a reduction of emitted CO2 eq. up to 80%. She will also explain how PI represents a paradigm-shift that, by a matter of fact will change the chemical industry in the upcoming years. Prof. Boffito will browse the available methods to intensify chemical processes, specifically those for carbon capture and utilization (CCU), and will explain why we need to apply them both to existing and new processes. Further, she will highlight how PI can contribute to attain the UN-SDGs.


Sustainable Chemical Synthesis of High Added-Value Compounds from Renewable Sources in Flow Regime

Julio Cezar Pastre, Associate Professor, University of Campinas - UNICAMP, Brazil

Raw materials from renewable sources, as well as agro-industrial waste, represent an attractive source of useful chemical functionalities. Our research group has already identified continuous flow processing as a fundamental technology for the valorization of such materials. Flow chemistry offers unique opportunities for the conversion of biomass derivatives into chemical compounds with higher-added value, since it brings numerous advantages in terms of unique process experience, scalability, and reduced environmental footprint. In this context, we will present our efforts for the synthesis of platform molecules (such as furanics) and new chemicals (monomers, nitrogenated aromatics) from biomass derivatives.

For some representative works, please see:
Marcon, H. M.; Pastre, J. C. “Continuous flow Meerwein-Ponndorf-Verley reduction of HMF and Furfural using basic zirconium carbonate”. RSC Advances 2022, 12, 7980-7989.

Galaverna, R.; Fernandes, L. P.; Browne, D. L.; Pastre, J. C. “Continuous Flow Processing as a Tool for the Generation of Terpene-Derived Monomer Libraries”. Reac. Chem. Eng. 2019, 4, 362-367.

Galaverna, R.; Ribessi, R. L.; Rohwedder, J. J. R.; Pastre, J. C. “Coupling Continuous Flow Microreactors to MicroNIR Spectroscopy: Ultra-Compact Device for the Facile In-line Reaction Monitoring”. Org. Process Res. Dev. 2018, 22, 780-788.

Galaverna, R.; Breitkreitz, M. C.; Pastre, J. C. “Conversion of D-Fructose to 5-(Hydroxymethyl)furfural: Evaluating Batch and Continuous Flow conditions by Design of Experiments and In-line FT-IR Monitoring”. ACS Sustainable Chem. Eng. 2018, 6, 4220-4230.


Fundamentals and Research Progress of Photochemical Microreaction Technology

Yuanhai Su, Professor, Shanghai Jiao Tong University, China

The research progress of our group in photochemical microreaction technology will be introduced, focusing on the design and construction strategies of photomicroreactors and its applications in synthesis of high-value chemicals associated with mass transfer, reaction kinetics and automatic control studies.


Mid-Afternoon Coffee and Tea Break and Networking in the Exhibit Hall


Contributions of Reaction Engineering Towards Efficient Photochemical Processes

Dirk Ziegenbalg, Professor of Chemical Engineering, Ulm University, Germany

The contribution will discuss the fundamentals of photochemical reaction engineering in the context of comprehensive reporting and characterization of laboratory experimental setups. It will be shown that synergistic interdisciplinary work can lead to an enhanced photocatalytic performance through dynamic irradiation strategies, in-depth mechanistic understanding, and improved reactor designs. Examples will be provided to illustrate this point.


Shu Kobayashi基調プレゼンテーション

Title to be Confirmed.

Shu Kobayashi, Professor, The University of Tokyo, Japan


Process Intensification for the Electrification of Chemical Manufacturing

Simon Kuhn, Professor, Department of Chemical Engineering, KU Leuven Belgium, Belgium

Small scale flow reactors have great advantages over conventional reactors, such as well-controlled flow patterns and increased surface-to-volume ratios, resulting in enhanced heat and mass transfer rates. Coupled with other benefits such as inherent safety allowing to perform reactions at elevated temperatures, pressures, or using highly reactive intermediates, they have become an attractive choice for the continuous manufacturing of chemicals and pharmaceuticals. However, these applications are still hindered by two important obstacles namely, weak convective mixing and issues regarding solids handling. Integrating ultrasound with small scale flow reactors has proven to be one of the more promising methods to address these issues. With selected examples, we will showcase the synergistic effect of ultrasound for particle synthesis, as well as electro- and photochemical processes. Exploiting these synergistic effects results in novel reactor concepts which will support the shift in chemical manufacture towards green and sustainable processes based on renewable energy sources.


Networking Reception in the Exhibit Hall with Japanese Beer and Sake


Close of Day 1 Conference Programming



Morning Coffee, Tea and Networking in the Exhibit Hall

Session Title: Photochemistry and Other Approaches Converging with Flow Chemistry


New Organic Electrosynthetic Processes Innovated by Flow Reactor Technology

Mahito Atobe, Professor, Graduate School of Science and Engineering, Yokohama National University, Japan

Organic electrosynthesis is expected to be a typical green chemistry process because it does not require any hazardous reagents and produces less waste than conventional chemical synthesis. In fact, a number of successful new green organic electrolytic processes have been developed to date. In addition, electrochemical methodologies based on new concepts have been also developed. These related studies have become an active research area. This presentation will outline a new organic electrosynthetic processes based on flow reactor technology, focusing on our research.


Ultrafast and Continuous Flow Synthesis of Zeolites

Toru Wakihara, Professor, The University of Tokyo, Japan

Zeolites have typically been synthesized via hydrothermal treatment, a process designed to artificially mimic the geological formation conditions of natural zeolites. This synthesis route, typically carried out in batch reactors like autoclaves, takes a time so long (typically, on the order of days) that the crystallization of zeolites had long been believed to be very slow in nature. Long periods of hydrothermal treatment also cause a burden on both energy efficiency and operational costs. Recently, we have reported the ultrafast syntheses of a class of industrially important zeolites within several minutes. Further shortening the crystallization time to the order of seconds would be a great challenge but can significantly benefit the mass product of zeolites as well as the fundamental understanding of the crystallization mechanism.


Fuji Techno Industries CorporationTriplex Plunger Driven Diaphragm Pumps

Harayuki Morikawa, General Manager, Fuji Techno Industries Corporation

We will be presenting two new offers to our portfolio.
1st our newly developed diaphragm pump, which unlike others, can handle a vast majority of slurry liquids.
2nd our AI software which further minimizes pulsation thru AI learning of the pulsation patterns and adjusting the motor speed.
In the introduction, we will explain the operating principles, performance, benefits of our innovative products.


Mid-Morning Coffee and Tea Break and Networking in the Exhibit Hall


Title to be Confirmed.

Noah Malmstadt, Professor, Mork Family Dept. of Chemical Engineering & Materials Science, University of Southern California, United States of America


Guangsheng Luo基調プレゼンテーション

Gas-liquid Micro Dispersion and its Performance

Guangsheng Luo, Professor, Tsinghua University, China

Gas-liquid process is one of the most common multiphase processes in chemical industry, and the environmental-friendly, high-effective, safe technology is always a chasing goal. The gas-liquid microreaction technology provides a new opportunity for the intensification of the gas-liquid process, and good gas-liquid microdispersion is the prerequisite for the excellent performance of the subsequent reaction process. Accordingly, this report concentrates on the progress of gas-liquid microdispersion technologies from the development of the microdevice structure and the enhancement of the microdispersion performance. A strategy that changes the gas kinetic energy to generate the desired bubble/liquid slug size and gas-liquid flow regime is proposed to generate the Taylor bubble flow, bubbly flow, and short bubble flow. Besides, by embedding a capillary in the gas channel and introducing a step structure to the liquid channel, the bubble size can easily break through the restriction of microchannel size and can be reduced to 25% of the microchannel size, and the aspect ratio of the Taylor bubble can break through the critical value of 1.0 and be reduced to 0.5. Importantly, the mass transfer specific surface area in the novel gas-liquid microdispersion device is higher up to 10400 m2/m3 and the liquid-side mass transfer coefficient could be larger up to 60×10-4 m/s, which has increased by 30% and 5-9 times compared with the best level in the conventional T-junction microchannel, respectively. Finally, the direction of the gas-liquid microdispersion technology is pointed out.


Networking Luncheon in the Exhibit Hall -- Network with the Exhibitors, View Posters and Engage with Colleagues
展示ホールでのネットワーキングランチ -- 出展者や同業者との交流、ポスターの観覧

Session Title: Emerging Trends and New Advances in the Flow Chemistry Ecosystem


Title to be Confirmed.

Shusaku Asano, Assistant Professor, Kyushu University, Japan


Continuous Flow Hydrogenations for the Chemical Manufacturing Industry

Christian Hornung, Research Group Leader, CSIRO, Australia

Our group at CSIRO has developed a new structured catalyst reactor system, termed Catalytic Static Mixers or CSMs, which is based on 3D printed metal scaffolds coated with a noble metal catalyst such as Pt, Pd, Ni, Ru or others. These tubular reactors are used in continuous flow hydrogenations for the chemical manufacturing industry as well as for hydrogen reforming on demand. With the help of computational fluid dynamics, the structure of the mixer lattice can be optimised for a range of different outputs, such as minimised pressure drop, maximised heat transfer or optimised mixing. CSMs can be classified as a hierarchical catalyst system, whereby different length scales are addressed by different preparation methods; cm-, mm- and µm-scale features are formed by the 3D printing process and classical engineering design while certain µm- and nm-scale features are created during the catalyst preparation and deposition procedures. This results in a highly efficient and versatile catalyst platform which can be used in a broad range of different applications including homogeneous liquid phase, emulsion, liquid-gas and gas phase processes.


Volker Hessel基調プレゼンテーション

Title to be Confirmed.

Volker Hessel, Professor, School of Chemical Engineering, The University of Adelaide, Australia


Mid-Afternoon Coffee Break and Networking in the Exhibit Hall


Title to be Confirmed.

Anil Kumar, Professor, Indian Institute of Technology Bombay, India

* 不測の事態により、事前の予告なしにプログラムが変更される場合があります。

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