Cambridge Healthtech Institute’s 21st Annual

Display of Antibodies
( 抗体のディスプレイ )

Tools for Creating the Next Generation of Biologics

2019年4月8〜9日

 

The 21st Annual Display of Antibodies is the cornerstone conference of the PEGS Summit and convenes leaders in the field year after year. This year’s meeting showcases innovation in discovery, design and engineering of biologics through molecular evolution using phage, yeast and other display methodologies. The proliferation of novel constructs is possible through methods to improve library design, pharmacological and biophysical properties to create drug molecules with greater potency, modes of action, target specificity and activity than previously achievable.

Preliminary Agenda

NEW APPLICATIONS FOR PHAGE DISPLAY

Protein-Directed Evolution in Genomic Contexts Using Mutagenesis and CRISPR/Cas9

Michael Krogh Jensen, PhD, Senior Researcher & Co-Principal Investigator, Technical University of Denmark, Novo Nordisk Foundation Center for Biosustainability

Constructing a Synthetic Biology Toolbox Using Phage Display Parts

C. Ronald Geyer, PhD, Professor, Pathology and Lab Medicine, University of Saskatchewan

Development of a Complex T7 Phage Display Library for Discovery of Biomarkers of Lung Diseases

Lobelia Samavati, MD, Associate Professor of Medicine, Department of Medicine, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine

KEYNOTE PRESENTATION: Engineering Membrane Proteins with Phage Display

Gregory A. Weiss, PhD, Professor, Chemistry, Molecular Biology & Biochemistry, University of California, Irvine

Cytosolic Delivery of Proteins by Bioreversible Esterification

Ronald T. Raines, PhD, Firmenich Professor of Chemistry, Department of Chemistry, Massachusetts Institute of Technology

Generating Pairs of Affinity Reagents for Sandwich Assays through MegaSTAR

Brian K. Kay, PhD, Professor & Head, Biological Sciences, University of Illinois, Chicago

Synthetic DNA Technologies Enable Antibody Discovery and Optimization

Aaron Sato, CSO, Twist Bioscience

ENGINEERING SMALL PROTEINS AND CONSTRAINED PEPTIDES

Yeast Display of Post-Translationally Modified Polycyclic Peptides

Wilfred A. van der Donk, PhD, Richard E. Heckert Endowed Chair in Chemistry, Director of Graduate Studies, Howard Hughes Medical Institute Investigator, Department of Chemistry, University of Illinois

Integrating Computational Design with Screening in Mammalian Cells for Novel Peptide Therapeutics

Philip M. Kim, PhD, Associate Professor, The Donnelly Centre for Cellular and Biomolecular Research, Departments of Molecular Genetics and Computer Science, University of Toronto

Platforms for the Generation and Screening of Cyclic Peptide Libraries

Ali Tavassoli, PhD, Professor, Chemical Biology, University of Southampton

NOVEL TECHNOLOGIES

Specificity and Polyreactivity: Designing Antibodies against Receptor Families for Desired Reactivity

Christilyn Graff, PhD, Director, Antibody Discovery and Engineering, Biogen 

A Platform-Enabling High-Throughput Functional Screening of Antibody Libraries

Ryan Kelly, PhD, Research Scientist, xCella Biosciences

A Novel Strategy for the Generation of Yeast Surface Display Antibody Fab Libraries

Stefan Zielonka, PhD, Group Leader & Principal Scientist, Protein Engineering & Antibody Technologies, Discovery Technologies, Global Research and Development, Merck KGaA

NGS ANALYSIS FOR ANTIBODY SELECTIONS: GETTING FROM SEQUENCE TO CLONE

Going Directly from Sequence to Clone: Isolation of Antibodies after Identifying Them by NGS

Fortunato Ferrara, PhD, Vice President, Specifica, Inc.

LakePharmaPresentation to be Announced

 

* 不測の事態により、事前の予告なしにプログラムが変更される場合があります。

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