ショートコース*

この学会のショートコースは、講義と双方向での討論を組み合わせた構成になっています。クラスは、講師と受講者が1対1で意見を交換することができる程度の規模であり、時間も質疑応答を含めた長さに設定されています。内容は、経験の浅い受講者を念頭に置いた基本的なものや、メインカンファレンスの研究発表では時間的に難しい技術的な側面を深く掘り下げる解説などさまざまです。講師となるのは、製薬会社や大学に所属し、それぞれの専門分野の第一人者として認められていたり、教員の経験を有していたりする方々です。

4月8日(月) 10:00 am – 1:00 pm

ショートコース1:共有結合フラグメント:標的ベーススクリーニングおよび表現型スクリーニングへの応用

Topics include: design principles of covalent fragment libraries; target-based and phenotypic screens using covalent fragments; strategies to grow fragments into drug leads; case studies of coupling covalent fragment growth with selectivity profiling in cells.
Instructor:
Alexander Statsyuk, PhD, Assistant Professor, Department of Pharmacological and Pharmaceutical Sciences, University of Houston

ショートコース2:医薬品の物理的特性のトレンド

Topics include: Properties that impact drug efficacy, development, delivery and formulation; including pKa, tautomerism, crystal structure interpretation among others. Use of computational tools.
Instructors:
Terry Stouch, PhD, President, R&D, Science for Solutions, LLC
Robert Fraczkiewicz, PhD, Team Leader, Simulations Plus, Inc.
Max Totrov, PhD, Principal Scientist, MolSoft, LLC

ショートコース3:GPCRベース創薬入門

Topics include: GPCR pharmacology, including allosteric modulation; biased signaling, persistent signaling, and accessory proteins; emerging GPCR screening methods, including cellular redistribution assays; affinity mass spectrometry and biosensors.
Instructor:
Annette Gilchrist, PhD, Professor, Department of Pharmacology, Midwestern University

4月8日(月) 2:00 – 5:00 pm

ショートコース5:リガンド受容体の分子間相互作用と薬剤設計

Topics include: medicinal chemistry drug design principles illustrated via case studies such as interpretation of atomic-level protein X-ray and modeled structures of binding model; understanding the relative amounts of potency gain from different interactions; and case studies to illustrate all the design strategies.
Instructor:
Maricel Torrent, PhD, Senior Scientist III, Molecular Modeling, AbbVie

ショートコース6:薬物クリアランスと薬物間相互作用を最適化する方法

Topics include: drug metabolism; CYP regulation; the role of bioactivation and how each affects lead optimization; and common assays and methodologies for predicting clearance and drug-drug interactions.
Instructors:
Zhengyin Yan, PhD, Principal Scientist, Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc.
Donglu Zhang, PhD, Principal Scientist, Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc.

ショートコース7:がん免疫療法に対応する新たな標的

Topics include: recently published data on immunology (STING, RIG- 1), epigenetic (HDAC, HAT), ubiquitin (DUBs, ligases) and autophagy targets; resulting strategies for development of new standalone or combination therapies for many types of cancers.
Instructors:
Wayne W. Hancock, MD, PhD, Professor of Pathology and Chief of Transplant Immunology, Children's Hospital of Philadelphia and University of Pennsylvania
Aditya Murthy, PhD, Scientist, Cancer Immunology, Genentech, Inc.
Additional Instructors to be Announced

4月8日(月) 6:00 – 9:00 pm

ショートコース9:フラグメントベースの設計に対応する手段と技術の進歩

Topics include: pros and cons of fragment-based approaches; what makes a good fragment; properties of a good fragment library; finding, validating and characterizing low affinity ligands; the importance of using orthogonal screening methods; and what to do with a fragment – growing, linking, and more.
Instructors:
Daniel A. Erlanson, PhD, Co-Founder, Carmot Therapeutics, Inc.
Ben Davis, PhD, Research Fellow, Biology, Vernalis Research

ショートコース10:リガンド発見のための多様性指向のプラットフォーム

Topics include: introduction to and comparison of these affinity-based drug discovery screening platforms: phage display, mRNA display and DNA-encoded libraries.
Instructor:
Svetlana Belyanskaya, PhD, Encoded Library Technologies, R&D Platform Technology & Science, GSK Boston
Additional instructor to be Announced

ショートコース11:PROTACと分子接着剤を利用した標的となるタンパク質の分解

Topics include: basic understanding of proteolysis-targeting chimeric molecules (PROTACs); applying PROTACS to target and degrade specific proteins of interest; case studies from instructors’ research.
Instructors:
Lara Gechijian, PhD, Scientist/Project Lead, Jnana Therapeutics; Former Graduate Student, Laboratory of Drs. James Bradner/Nathanael Gray, Harvard Medical School
Eric Fischer, PhD, Assistant Professor, Cancer Biology, Dana-Farber Cancer Institute/Harvard Medical School
Alexander Statsyuk, PhD, Assistant Professor, Department of Pharmacological and Pharmaceutical Sciences, University of Houston

4月10日(水) 6:30 – 9:00 pm

ショートコース13:ユビキチンプロテアソーム系の生化学と薬理学

Topics include: basic mechanistic biochemistry and pharmacology of the ubiquitin proteasome system, including E1, E2, E3, and deubiquitinating enzymes; signaling pathways regulated by UPS; the effect of small molecules on UPS-regulated pathways; assays and technologies for discovering enzyme inhibitors of the UPS system.
Instructor:
Alexander Statsyuk, PhD, Assistant Professor, Department of Pharmacological and Pharmaceutical Sciences, University of Houston

ショートコース14:化学研究者のための免疫学基礎講座

Topics include: review of the immune system’s cellular players; review of the inflammatory process; autoimmune and inflammation-related diseases; current treatment landscape; promising drug targets; and principles in immuno-oncology (e.g., checkpoint blockade).
Instructors:
Songqing Na, PhD, Senior Scientist, Biotechnology & Autoimmunity Res-AME, Eli Lilly and Company
Additional Instructor to be Announced

ショートコース15:創薬に向けた大環状化合物の研究:可能性、課題、戦略

Topics include: unique characteristics of macrocycles; factors affecting cell permeability and PK/ADME properties; synthetic strategies for macrocyclic compound libraries and macrocyclization challenges; and drug discovery and development examples.
Instructors:
Eric Marsault, PhD, Professor, Medicinal Chemistry and Pharmacology, University of Sherbrooke
Mark Peterson, PhD, COO, Cyclenium Pharma, Inc.

ショートコース16:GPCR構造ベースの創薬

Topics include: methodologies for the characterization and crystallization of GPCRs; a review of X-ray crystallographic and cryoEM GPCR structures and their lessons; biophysical tools (NMR, fluorescence spectroscopy, EPR, SPR and computational approaches) for observing function-related conformational dynamics of GPCRs; implications of structural knowledge on drug discovery especially related to allosteric modulation by small molecules, ions, and engineered partner proteins.
Instructors:
Matthew Eddy, PhD, Assistant Professor, Chemistry, University of Florida
Additional Instructor to be Announced


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