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Cambridge Healthtech Institute 第15回

Recombinant Protein Therapeutics
( 組み換えタンパク質療法 )

融合タンパク質およびそれ以外のタンパク質

2019年1月14日~15日

 

組み換えタンパク質療法をテーマにしたこのカンファレンスプログラムでは、この分野をリードする世界各国の研究者が非抗体療法の最新動向を明らかにします。焦点となるのは、融合タンパク質をベースにした治療薬の多様な設計であり、研究開発から承認後までの各段階で得られた最新のデータやケーススタディも披露されます。

Final Agenda

1月13日(日)

4:00 - 6:00 pm Pre-Conference Registration

1月14日(月)

7:00 am Registration and Morning Coffee

融合タンパク質治療薬の分析と特性評価

9:00 Welcome by Conference Organizer

Mary Ruberry, Senior Conference Director, Cambridge Healthtech Institute

9:05 Chairperson’s Opening Remarks

Uli Binder, MSc, CTO, XL-protein GmbH


KEYNOTE PRESENTATION

9:10 The Evolving Science and Long-Term Outcomes of Fc Fusion Factors

Jennifer Dumont, PhD, Executive Director, Medical Affairs, Bioverativ, Inc.


 

9:50 Selection of the Recommended Phase II Dose for M7824, a Bifunctional Fusion Protein Targeting TGF-β and PD-L1

Yulia Vugmeyster, PhD, Associate Director, Clinical Pharmacology, EMD Serono R&D Institute, Inc.

M7824 (MSB0011359C) is an innovative, first-in-class, bifunctional fusion protein composed of a human IgG1 mAb against PDL1 fused with two extracellular domains of TGF-β receptor II to function as a TGF-β “trap.” The selection of the recommended Phase II dose (RP2D) for M7824 will be presented. The current RP2D dose selection is informed by preclinical and clinical data, such as tolerability/safety, efficacy, pharmacokinetic and pharmacodynamic profiles, and is supported by the population PK and exposure-response modeling.

10:20 Networking Coffee Break

融合タンパク質治療薬による疾病の治療

10:45 Proinsulin-Transferrin Fusion Protein to Overcome Insulin Resistance

Wei-Chiang Shen, PhD, John A. Biles Professor, Pharmacology and Pharmaceutical Sciences, University of Southern California School of Pharmacy

We have previously shown that proinsulin-transferrin fusion protein (ProINS-Tf) is a highly liver-targeted and long-lasting insulin analog for the treatment of diabetes in mouse models. Recently, we have found that the liver-activated ProINS-Tf, due to simultaneous binding to both transferrin and insulin receptor, can overcome insulin-resistance in cell cultures and in NOD mice. ProINS-Tf can serve as a model of insulin analogs for treating insulin-resistance in diabetes and other diseases.

11:15 IL-DR2 Fc Is a Novel Regulator of Immune Homeostasis and Inducer of Antigen-Specific Tolerance

Stephen D. Miller, PhD, Judy Gugenheim Research Professor, Director, Interdepartmental Immunobiology Center, Microbiology-Immunology, Northwestern University Medical School

ILDR2 is a member of the Ig superfamily and has a putative role in pancreatic islet health and survival. We recently found a novel role for ILDR2 in delivering inhibitory signals to T cells. ILDR2-Fc displays a unique mode of action, combining immunomodulation, regulation of immune homeostasis, and re-establishment of Ag-specific immune tolerance via induction of regulatory T cells. These findings support the potential of ILDR-Fc as a promising therapeutic approach for the treatment of autoimmune diseases.

11:45 xB3 Platform Delivers a Protein-Based Interleukin 1 Receptor Antagonist across the BBB and Ameliorates Neuropathic Pain in a Preclinical Model

Mei Mei Tian, PhD, Vice President and Head, External Research, Bioasis Technologies, Inc.

Utilizing a 12 amino-acid peptide, xB3, we have shown improved brain delivery of antibody payload. xB3-antibody fusion demonstrated similar plasma kinetics to control antibody, however, with significantly increased brain exposure for the duration of the study. In a neuropathic pain model, fusion to interleukin-1receptor antagonist is able to induce significant and durable analgesia following peripheral administration. These data demonstrate the utility of xB3 in delivering therapeutic levels of drug to the brain.

12:15 pm Sponsored Presentation (Opportunity Available)

12:45 Session Break

12:55 Luncheon Presentation (Sponsorship Opportunity Available) or Enjoy Lunch on Your Own

がん治療のための融合タンパク質治療薬

2:00 Chairperson’s Remarks

Vladimir Muzykantov, MD, PhD, Professor, Pharmacology, The Center for Translational Targeted Therapeutics and Nanomedicine (CT3N) and Systems Pharmacology, Perelman School of Medicine, University of Pennsylvania

2:05 Antibody-Cytokine Fusion Proteins Targeting Tumor Associated Antigens for the Treatment of Malignancy

Sherie Morrison, PhD, Distinguished Research Professor, Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles

Many cytokines have anti-tumor efficacy, however, their utility for treating malignancy is often limited by toxicities that are dose limiting. To address this problem, we have genetically fused cytokines to antibodies that recognize tumor-associated-antigens. Among other things, we have used this strategy to target interferons to tumor cells using anti-CD20 and anti-CD138 specific antibodies. We have found these antibody fusion proteins effective in the treatment of both lymphoma and myeloma.

2:35 Optimization of a Bispecific Anti-CD3 Antibody-Folate Conjugate for the Treatment of Ovarian Cancer

Harun Rashid, PhD, Senior Principal Scientist, Molecular Technology, Ambrx, Inc.

Here, we report the optimization of an anti-CD3 Fab-folate conjugate that targets cytotoxic T cells to folate receptor positive (FR+) tumor cells for optimal efficacy, reduced toxicity and optimal pharmacokinetic (PK). The optimized conjugates showed potent and selective in vitro activity, good serum half-life, and potent in vivo activity in xenograft mouse models. This semi-synthetic approach shows promise for the generation of additional anti-CD3 bispecific agents using small molecule ligands selective for other TAAs.

3:05 Find Your Table and Meet Your BuzZ Session Moderator

3:15 BuzZ Sessions with Refreshments

Join your peers and colleagues for interactive roundtable discussions.

 

がん治療のための融合タンパク質治療薬 (続き)

4:30 Advancing Targeted Protein Therapeutics (TPTs) in Clinical Drug Development

Jeannick Cizeau, PhD, Director, Research, Sesen Bio, Inc.

The design and differential mechanism of action of Sesen’s TPTs comprising an antibody fragment genetically fused to a protein toxin versus traditional small molecule drugs used for ADCs will be discussed. Data from an ongoing pivotal Phase III trial in non-muscle invasive bladder cancer will be presented to illustrate the rationale design approach of TPTs for use in clinical oncology.

5:00 Hexavalent Agonists Targeting Co-Stimulatory Receptors of the TNFR-Superfamily for Cancer Immunotherapy

Christian Gieffers, PhD, Vice President, Analytics/Protein Chemistry, Apogenix AG

Apogenix’s novel hexavalent TNFR-SF agonists (HERA) are developed for the immunologic treatment of cancer. The construction principle is based on trivalent molecular mimics of the TNF-SF Receptor binding domains fused to a dimerization scaffold. The resulting hexavalent fusion proteins are potent TNFR-SF agonists that activate distinct immune cell populations. HERA compounds show single-agent anti-tumor activity and provide exciting opportunities for combinatorial treatment.

5:30 Prospects of PASylation for the Design of Protein Therapeutics and Tumor Imaging Reagents

Uli Binder, MSc, CTO, XL-protein GmbH

PASylation®, the genetic fusion or chemical coupling of proteins or peptides with conformationally disordered polypeptides comprising the L-amino acids Pro, Ala, and/or Ser (PAS), is a superior way to enlarge the hydrodynamic volume and to extend plasma half-life. Further to illustrating the fundamental concepts of PASylation technology, this presentation will highlight a first proof-of-concept tumor imaging study in a human patient.

6:00 - 7:15 Welcome Reception in the Exhibit Hall with Poster Viewing

7:15 Close of Day

1月15日(火)

8:00 am Registration and Morning Coffee

特性の改善

8:30 Chairperson’s Remarks

Yulia Vugmeyster, PhD, Associate Director, Clinical Pharmacology, EMD Serono R&D Institute, Inc.

8:35 Engineered FcRn Binding Fusion Peptides for Half-Life Extension

Jeffrey Boyles, MSc, Research Scientist, Biotechnology Discovery Research, Eli Lilly and Company

The therapeutic potential of small proteins, peptides, and mAb derived domains can be significantly limited by their rapid peripheral clearance in vivo. We show that small FcRn binding peptides (FcRnBPs) fused to the N- and/or C-termini of a Fab can significantly improve the pharmacokinetics of the protein in cynomolgus monkeys. The extent of this benefit can be modulated by number, structure, and post-translational modifications of the FcRnBP.

9:05 Developing a Conjugation-Based Multivalent Ab Format

Diego Ellerman, PhD, Principal Scientific Researcher, Protein Chemistry, Genentech, Inc.

A multivalent Ab format based on protein conjugation was developed (TRAC) to enable a plug and play system for the rapid screening of new multispecific/multivalent Abs. The building blocks used are mAbs and Fabs with good expression yields and stability. A conjugation site was identified that supports high conjugation rates, an efficient process and a stable molecule. We provide examples of different TRACS that require concurrent binding of all Fabs for their biological activity.

9:35 Sponsored Presentation (Opportunity Available)

9:50 Coffee Break in the Exhibit Hall with Poster Viewing

11:00 Therapeutic Fusion Proteins Targeted to Blood and Vascular Cells

Vladimir Muzykantov, MD, PhD, Professor, Pharmacology, The Center for Translational Targeted Therapeutics and Nanomedicine (CT3N) and Systems Pharmacology, Perelman School of Medicine, University of Pennsylvania

Conjugating biotherapeutics including thrombomodulin with scFv to blood cells boosts bioavailability, while conjugating with scFv binding to endothelial determinants provides endothelial targeting. Selecting determinants that permit fusion cooperation with cofactors boosts the effect. Further, dual targeting of two fusions delivering collaborative cargoes to adjacent epitopes maximizes binding and effect. Vascular targeting of anti-thrombotic and anti-inflammatory fusions affords beneficial effects unrivaled by untargeted counterparts in animal models of acute lung injury, ischemia-reperfusion and sepsis.

11:30 Enabling and Expanding Therapeutic Development of Microbial-Derived Biologics through the Use of Tolerogenic Nanoparticles

Kei Kishimoto, PhD, CSO, Selecta Biosciences

We have developed tolerogenic nanoparticles to induce antigen-specific immune tolerance to biologic drugs and prevent the formation of anti-drug antibodies. I will present three case studies: 1) Phase II clinical data for a fungal-derived uricase enzyme for the treatment of severe gout; 2) Phase I clinical program of a bacterial-derived recombinant immunotoxin for the treatment of mesothelioma; and 3) enabling repeat dosing of an AAV viral vector for gene therapy.

12:00 pm Sponsored Presentation (Opportunity Available)

12:30 Session Break

12:40 Luncheon Presentation (Sponsorship Opportunity Available) or Enjoy Lunch on Your Own

1:10 Close of Recombinant Protein Therapeutics Conference


5:45 - 8:45 Recommended Dinner Short Courses*

SC1: Introduction to CAR-T Engineering for Protein Scientists

SC4: Immunogenicity for Biologics

Click here for more details.

*Separate registration required

* 不測の事態により、事前の予告なしにプログラムが変更される場合があります。

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