Targeting HBV

Cambridge Healthtech Institute 第1回

第15回Discovery on Targetの一翼を担うイベント


Final Agenda


· September 25 Symposium: Targeting HBV

· September 25 Short Course: Immunology Basics for Chemists

· September 26-27 Conference: NASH and Fibrosis

· September 27-28 Conference: Autoimmune and Inflammation Drug Targets

· September 27 Short Course: CRISPR-Based Gene Editing for Targeted Therapies

· September 28-29 Symposium: Tackling Rare Diseases

Monday, September 25

7:00 am Registration Open and Morning Coffee

Targeting HBV Proteins

7:55 Welcome Remarks

Anjani Shah, Ph.D., Conference Director, Cambridge Healthtech Institute

8:00 Chairperson's Opening Remarks

Richard Colonno, Ph.D., CSO, Assembly Biosciences

8:10 Targeting HBV Surface Antigen with Nucleic Acid Polymers (NAPs): Updates on Pharmacology, Toxicity and Achieving Functional Cure of HBV and HDV Infection

Andrew Vaillant, Ph.D., CSO, Replicor

NAPs have a unique ability to eliminate circulating HBsAg, potentiating the ability of immunotherapy to achieve functional control of HBV and HDV infection. Recent breakthroughs in modeling NAP effects in vitro and updated pre-clinical and clinical data continue to advance the understanding of how NAPs work and their clinical impact against HBV and HDV infection.

8:40 HBV Capsid Assembly Inhibitors

Rene Rijnbrand, Ph.D., Vice President, Biology, Arbutus

AB-423 is an HBV capsid inhibitor that has shown in vitro and in vivo antiviral activity. AB-423 has been shown to impact the HBV life cycle at two distinct stages: the formation of novel core particles, required for the formation of rcDNA, and the unpacking of the rcDNA from these particles, required for cccDNA formation. AB-423 acts additively to synergistically with siRNA and nucleoside inhibitors.

9:10 Targeting HBV Core Protein to Achieve Higher Cure Rates

Richard Colonno, Ph.D., CSO, Assembly Biosciences

With HBV cure rates below 5%, additional novel therapies are needed. HBV Core protein (Cp) plays a critical role in multiple steps related to the generation of cccDNA, a key viral moiety responsible for infection and maintenance of chronic infection. We are developing a series of novel CpAMs (Cp Allosteric Modifiers) that target Cp and reduce cccDNA levels in infected cells via multiple mechanisms.

9:40 Networking Coffee Break with Poster Viewing

Targeting HBV Proteins (Cont.)

10:10 RNAi Interference: A New Tool in the Toolbox for Treatment of HBV

Amy Lee, Ph.D., Senior Director, In vivo Pharmacology, Arbutus

ARB-1467 and ARB-1740 are RNAi therapeutics currently in Phase II MAD clinical studies. These agents are designed to inhibit viral replication, cleave HBV transcripts, and lower all viral antigens. Reducing HBV proteins, particularly HBsAg, is expected to abrogate viral suppression of immune function and facilitate reinvigoration of the host response/defense. Preclinical studies suggest that combination of RNAi with standard-of-care drugs can enhance control of HBV.

10:40 RNAi in HBV, the Next Backbone Therapy for Use in Combinations?

Bruce Given, M.D., COO, Head of R&D, Arrowhead Pharmaceuticals

Arrowhead was the first broadly used RNAi studied in HBV. Based on our experience in treatment of naive and experienced patients, we believe that RNAi will become a backbone therapy, together with NUCs, in the next generation of combination therapies seeking functional cure.

11:10 Sponsored Presentation (Opportunity Available)

11:40 Enjoy Lunch on Your Own

Targeting Virus/Host Interactions

1:10 pm Chairperson's Remarks

Amy Lee, Ph.D., Senior Director, Invivo Pharmacology, Arbutus

1:20 KEYNOTE PRESENTATION: Targeting HBV: Integrating Approaches

Pierre Raboisson, Ph.D., Head, IDV Europe Discovery, Janssen

1:50 Entry Inhibition as a Therapeutic Concept for the Treatment of Hepatitis B and D Virus Infections

Stephan Urban, Ph.D., Professor, Department of Infectious Diseases, Translational Virology, University Hospital Heidelberg

Entry inhibition is an interesting, potentially curative opportunity to treat viral infections. The development of Myrcludex B as a potent inhibitor of the HBV/HDV receptor NTCP opened a novel therapeutic option to treat chronically infected patients. In my talk, I will discuss the current state of the art of entry inhibition for HBV/HDV and discuss, if such strategies might become important for future therapeutic regiments.

2:20 Targeting HBx and Smc5/6 Interactions

Dara Burdette, Ph.D., Research Scientist II, Discovery Virology, Gilead Sciences

2:50 Networking Refreshment Break with Poster Viewing

Immunomodulators for HBV and Beyond

3:30 Achieving Functional Cure in HBV: The Dinucleotide SB 9200 as an Immuno-Modulatory Anti-HBV Agent

R. P. (Kris) Iyer, Ph.D., Co-Founder and CSO, Spring Bank Pharmaceuticals, Inc.

Over 350 million people worldwide are infected with chronic hepatitis B (CHB). While life-long therapy with direct-acting nucleoside and nucleotide antivirals (DAAs) effectively suppress viral replication, development of resistance and toxicity to DAAs remain a significant problem. In CHB, the cellular innate and adaptive immune responses critical for antiviral defense are disabled. SB 9200, a novel synthetic dinucleotide, activates cellular viral sensors RIG-I and NOD2, restores the production of IFNs, ISGs and antiviral cytokines, and shows potent in vitro and in vivo antiviral activity. SB 9200 is being currently evaluated both as a monotherapy and in combination with Viread® in global Phase II clinical trials.

4:00 CRV431: Exploring the Cyclophilin Inhibitor Mode of Action in HBV

Robert T. Foster, PharmD, Ph.D., CSO, ContraVir Pharmaceuticals Inc. and Professor, Pharmacy & Pharmaceutical Sciences, University of Alberta, Canada

CRV431 is a proprietary host targeting cyclophilin inhibitor designed for the treatment of hepatitis B viral infection. The detailed mode of action of CRV431 is being examined and has thus far been shown to abrogate binding between cyclophilin A and two important viral proteins, HBsAg and HBx. These proteins play a vital role in the pathogenesis of infection and the propagation of liver disease.

4:30 Presentation to be Announced

5:00 Close of Symposium

5:00 Pre-Conference Dinner Short Course Registration

Click here for details on short courses offered.

* 不測の事態により、事前の予告なしにプログラムが変更される場合があります。

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